Fueled by extensive studies, scientific evidence demonstrating the safety, tolerability, and efficacy of red yeast rice (RYR) continues to mount. The first use of RYR was documented in 800 A.D., during the Tang Dynasty. Subsequently, during the Ming Dynasty (1368-1644), the manufacturing process was published in the ancient Chinese pharmacopoeia. The typical Asian diet contains 14-55 grams of naturally occurring RYR per day.
The potential benefits of consuming RYR or its supplement form, RYRE (red yeast rice extract), are multifaceted. In Traditional Chinese Medicine, the powdered form is called Hong Qu, Hong Mi, or Chi Qu. Considered sweet, acidic, and warm, it is used to strengthen the spleen and stomach, thereby promoting digestion, invigorating blood circulation, and eliminating blood stasis. In vitro work suggests that RYR downregulates adipogenic transcription factors, such as PPAR gamma and other genes that differentiate adipocytes.
Researchers believe that certain fermentation products of RYR influence enzymes involved in cholesterol biosynthesis. In addition, a study utilizing hamsters concluded that “the activity of RYR is, at least, partially mediated by enhancement of acidic sterol excretion.” RYR also contains various pigments, tannins, phytochemicals such as sterols and isoflavones, and mono-unsaturated fatty acids, all of which may work synergistically with the active fermentation products.
Since 1996, there have been no fewer than nine randomized, controlled RYR/RYRE trials involving thousands of subjects. Studies since the 1970s have demonstrated that RYRE supports healthy blood lipid levels already in the normal range. The medical literature associated with these studies includes comparative, case series, and dosing studies. Because there is evidence that use of RYR can deplete coenzyme Q10, co-supplementation is recommended.
In its natural state, RYRE may contain a secondary metabolite of the Monascus species called citrinin, which is a mycotoxin. Accordingly, Revolution Health & Wellness carefully tests and documents every batch of RYRE raw material to assure its safety. Repeated analysis has found Revolution Health & Wellness’s Red Yeast Rice to be so well within the limits of safety that it earns the designation “citrinin-free.”
Take one capsule one to three times daily, or as directed by your healthcare practitioner.
Individuals that have liver disease, have had an organ transplant, or are taking prescription drugs should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.
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14. Assay available upon request.