Although docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) can be obtained by including cold-water fish in their diet, many individuals restrict their fish consumption due to the possibility of contaminants. OmegaPure Liquid is sourced from sardines and anchovies. The supplier of the raw materials uses the most current and applicable industry-standard oil-removal methods including a true molecular distillation process and a final refining process to ensure the effective removal of man-made pollutants such as PCBs, dioxins, and mercury. Independent third-party testing in an FDA-registered laboratory of each batch of XYMOGEN®s OmegaPure Liquid confirms freshness, potency, purity, and safety. This oil meets the standards needed to comply with California Proposition 65’s most up-to-date list, which itemizes chemicals known to cause cancer or birth defects or other reproductive harm and is published annually by the State of California Environmental Protection Agency.
Omega-3 polyunsaturated fatty acids (PUFAs) play a critical role in the normal development of the brain and central nervous system of the fetus and infant. Functioning solely via cell membranes that attach them to phospholipid molecules, DHA and EPA are integral to numerous processes affecting membrane fluidity and gene regulation. DHA is the primary structural fatty acid in the brain’s gray matter (~ 40%) and the eye’s retina, and optimizes signal transmission in these organs and throughout the nervous system. Low levels of this fatty acid have been associated with poor memory, impairment in the ability to recognize and comprehend written words, poor night vision, and other neurological dysfunction. Meta-analyses confirm that DHA supports a healthy mood. DHA also supports healthy immune system balance and the body’s healthy response to inflammation.
EPA is a long-chain omega-3 fatty acid. Although EPA does not significantly affect clotting factors, it does reduce blood viscosity and blood triglycerides. The low incidence of acute myocardial infarction among native Greenland Eskimos launched keen interest in EPA in the 1970s. EPA is a precursor for the platelet aggregation inhibitor, prostaglandin-3, and for the eicosanoids, thromboxane-3 and leukotriene-5. It competes with arachidonic acid for inclusion in the lipoxygenase and cyclooxygenase pathways.
Directions:
Once daily, measure one teaspoon (5 mL) OmegaPure LiquidTM and consume as is, or add to your favorite drink, or use as directed by your healthcare practitioner.
References:
1. de Souza AS, Fernandes FS, Tavares do Carmo MG. Effects of maternal malnutrition and postnatal nutritional rehabilitation on brain fatty acids, learning, and memory. Nutr Rev. 2011 Mar;69(3):132-44. [PMID: 21348877]
2. Caputo M, Zirpoli H, Torino G, et al. Selective regulation of UGT1A1 and SREBP- 1c mRNA expression by docosahexaenoic, eicosapentaenoic, and arachidonic acids. J Cell Physiol. 2011 Jan;226(1):187-93.[PMID: 20648548]
3. Simopoulos AP. Evolutionary aspects of diet: the omega-6/omega-3 ratio and the brain. Mol Neurobiol. 2011 Jan 29. [Epub ahead of print] [PMID: 21279554]
4. Yurko-Mauro K. Cognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline. Curr Alzheimer Res. 2010 May 1;7(3):190-6. [PMID: 20088810]
5. Lindmark L, Clough P. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. J Med Food. 2007 Dec;10(4):662-6. [PMID: 18158838]
6. Schweigert FJ, Reimann J. Micronutrients and their relevance for the eye- function of lutein, zeaxanthin and mmega-3 fatty acids. Klin Monbl Augenheilkd. 2010 Aug 25. [Epub ahead of print] [PMID: 20740395]
7. Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long-chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr. 2009 Oct;28(5):525-42. [PMID: 20439549]
8. Seki H, Sasaki T, Ueda T, et al. Resolvins as regulators of the immune system. Scientific World Journal. 2010 May 4;10:818-31. [PMID: 20454764]
9. Balvers MG, Verhoeckx KC, Plastina P, et al. Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties. Biochim Biophys Acta. 2010 Oct;1801(10):1107-14. [PMID: 20601112]
10. Terano T, Harai A, Hamazaki T, et al. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects. Atherosclerosis. 1983 Mar;46(3):321- 31. [PMID: 6303363]
11. Oya J, Nakagami T, et al. Intake of n-3 polyunsaturated fatty acids and non- alcoholic fatty liver disease: a cross-sectional study in Japanese men and women. Eur J Clin Nutr. 2010 Oct;64(10):1179-85. [PMID: 20683463]
12. Ponte E, Cafagna D, Balbi M. Cardiovascular disease and omega-3 fatty acids. [Article in Italian]. Minerva Med. 1997 Sep;88(9):343-53. [PMID: 9411311]
13. Sakamoto Y, Node K. Anti-atherosclerotic effect of fibrates and eicosapentaenoic acid. [Article in Japanese]. Nippon Rinsho. 2011 Jan;69(1):87-91. [PMID: 21226266]
