D-Z-No-Phi

Xenobiotics (chemicals foreign to a living organism) have the potential to disrupt metabolism and negatively affect cellular health.[1-3] Classes of xenobiotics include pesticides, petroleum-based plastic compounds, industrial chemicals, and xenoestrogens. D-Z-No-Φ comprises an array of compounds to support detoxification and elimination of these potentially toxic molecules. Man-made xenoestrogens (including BPA, DDT, and DES), act as endocrine disruptors and can alter hormonal function in sensitive tissues including breast, uterus, cervix, and prostate.[4,5] Xenoestrogens at very low levels are believed to disrupt neurotransmitter balance, glucose homeostasis, normal reproduction, and healthy metabolism.[5] Detoxification of xenobiotics is a complex process that requires micronutrients, phytonutrients, energy, and adequate antioxidant support for safe and effective completion.*[6]

Antioxidant and Detoxification Support Several nutrients support antioxidant activity, both phases of detoxification, and the health and function of the liver (the major site of detoxification). Milk thistle extract contains silymarin, a compound found to limit the entry of hepatotoxins, donate sulfhydryl groups for detoxification, and increase hepatic glutathione by over 35%.[7] Its action in the liver reduces fat peroxidation and fibrous tissue formation, supports a normal immune and inflammatory response, promotes protein synthesis and tissue regeneration, and supports glucuronidation and glutathione levels.[8] Alpha-lipoic acid is both water- and fat-soluble. It supports glutathione metabolism, helps regenerate antioxidant vitamins C and E, and helps maintain the ratio of reduced-to-oxidized CoQ10 in mitochondria.[7] The redox couple of lipoic acid and dihydrolipoic acid stabilizes NF-kappaB transcription and may help support healthy immune functions in the body.[9,10] Methylselenocysteine (MSC) is considered a well-tolerated form of the trace element selenium and may support normal cell-life regulation.[11] Selenium provides antioxidant support via glutathione peroxidase and manganese superoxide dismutase (MnSOD) activity.[12] N-acetyl-cysteine (NAC) may significantly increase glutathione in the body, which, in turn, is incorporated into crucial antioxidant and detoxification enzymes. Glutathione supports antioxidant activity, phase II detoxification, and the normal breakdown of metabolites, toxins, and other compounds. NAC supports phase II sulfation reactions as well.[7] Calcium D-glucarate has been added to support glucuronidation. 5-methyltetrahydrofolate (5-MTHF) is present as Quatrefolic® (a stable, bioavailable form of folate) to support methylation, energy generation, and phase l and phase ll activity.*

Phytonutrients A variety of phytonutrients support antioxidant activity in the body. Green tea catechins have been found to assist in free-radical scavenging, support detoxification through modification of phase I and phase II enzymes, and support normal cell-life regulation via multiple signaling pathways.[13,14] Bioflavonoids, including resveratrol, quercetin, and the highly absorbable FlavitPURETM form of dihydroquercetin (DHQ), support phase I detoxification as well as intermediary antioxidant protection.[1] Pterostilbene, a highly absorbable, methylated form of resveratrol, is thought to work together with quercetin in supporting normal cell-life regulation.[15] Turmeric extract provides curcumin, a phytonutrient valued for its promotion of antioxidant activity, support of metabolic detoxification, and modulation of cytokine production.[16,17] BioPerine®, a patented form of piperine from black pepper, has been added to enhance the absorption of nutrients, particularly curcumin.*[18]

Xenoestrogen Metabolism D-Z-No-Φ provides diindolymethane (DIM) and glucoraphanin as SGS. DIM promotes healthy estrogen metabolism and creates a better balance of estrogen metabolites (2-OH, 4-OH, 16-alpha-OH) through phase I cytochrome P450 enzyme induction and promotion of 2-hydroxylation.[19,20] The action of DIM is complemented by glucoraphanin, which supports long-term antioxidant activity and phase II detoxification of less-desirable estrogen metabolites and xenoestrogens.[21,22] Glucoraphanin and its metabolite sulforaphane are found to be effective, long-acting, indirect antioxidants and significant inducers of phase II detoxification enzymes.[23,24] These actions may help support healthy estrogen balance and may be crucial for the health of estrogen-sensitive tissue.*

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