Br’Ache Away

Br’Ache Away, a member of Revolution Health & Wellness Clinic’s Exclusive and Patented (“EP”) line, is the result of Revolution Health & Wellness Clinic’s partnership with BiotanikaTM, a Canadian company that develops evidence-based natural pain management products. It is among a trio of formulas that also includes Joint Health and Inflam-X Gel. The formulation of Br’Ache Away began with investigation of the potential of the lowest possible doses of traditional herb extracts to act additively or synergistically to reduce inflammation and pain. Biotanika used three recognized models of inflammatory diseases for its pre-clinical test protocols. These protocols resulted in formulas benchmarked with current standards of care used in western medicine.*

The primary goal of the first clinical trial of the three formulas was to assess the safety and efficacy for the relief of pain in fourteen patients with either low back pain, joint (knee, shoulder, or hip) pain, or muscular or articular pain (the majority had moderate-to-severe pain). These patients had been seeking alternative therapies to NSAIDs or surgery. As is most often seen in patients scheduled for knee replacement surgery or who have had knee replacements, benefit was nil. However, all patients with low back, hip and shoulder pain demonstrated significant benefit.*

Devil’s Claw (Harpagophytum procumbens) exerts anti-inflammatory and analgesic effects possibly by suppressing COX-2 and iNOS expressions,[1] reducing leukotrienes,[2] inhibiting TNF-alpha and reducing the production of metalloproteinase MMP-1, MMP-3 and MMP-9.*[3]

Black Currant (Ribes nigrum) decreases joint tenderness and pain.[4] Prodelphinidins, the major compounds isolated from Ribes nigrum leaves, were shown to inhibit PGE2 synthesis through the inhibition of COX enzymes.*[5]

Green-Lipped Mussel (Perna canaliculus), a native New Zealand shell fish contains 20% omega-3 fatty acids, as well as other pharmacologically-active material that appears to abolish inflammatory mediators and inhibit prostaglandin biosynthesis[6,7,8] thereby reducing joint pain.*[9,10,11]

Willow Bark (Salix alba) may relieve joint pain [12,13,14] by inhibiting COX-2-mediated PGE2 release and to a lesser degree, release of TNF-alpha, IL-1beta and IL-6.*[15]

Feverfew (Tanecetum parthenium) contains the active component, parthenolide that produces a dose- dependent inhibition thromboxane B2 and leukotriene B4 synthesis and inhibits secretion of TNF-alpha, IL-1 and IL-6.*[16]

Meadowsweet (Spirea ulmaria) has been used for centuries for analgesia. It contains salicylate derivatives and possesses high antioxidant activities.*[17]

Birch (Betula alba), traditionally to heal sores and relieve pain,[18,19] contains salicylic acid and has anti- inflammatory, antispasmodic, and diuretic properties.*

Directions

Take 2 capsules in the morning and 2 capsules in the evening, with water.

References