***This content was written for Revolution Health & Wellness Clinic for marketing purposes only.***
Coenzyme Q10 is a biologically active, natural vitamin-like substance belonging to a group of compounds called ubiquinones. Structurally similar to vitamin K, it is present in animal protein and can be synthesized in the body. However, a variety of factors, including aging, may cause CoQ10 depletion.
Despite its poor absorption (0.6-1.0%), pure crystalline (powdered) CoQ10 was the industry standard from the 1970s to the mid-1990s. A variety of forms and delivery systems offering somewhat improved absorption (2.3-5%) have entered the market since 1995; however, these forms have been unstable and crystallized, making them difficult for the body to absorb.
CoQ10 represents a new generation of CoQ10 supplements. Unlike many others in today’s marketplace, this generation is crystal-free when examined by a light microscope. This soy-free formulation contains five lipids to aid in dissolving CoQ10 crystals into single molecules, stabilizing the formula to prevent re-crystallization and facilitating passive diffusion to enhance absorption.*
Absorption involves several phases in the movement of CoQ10 as it passes through a portion of the digestive tract, into the lymphatics, and into general circulation, where it becomes bioavailable. Absorption is determined by the time-based changes in the amount of CoQ10 that appear in the blood plasma after the ingestion of a single known dose. Bioavailability refers to the amount of CoQ10 accumulated in the blood plasma over an extended time after taking a known constant daily dose.
Take one softgel one to two times daily, or as directed by your healthcare practitioner. Optimal results may be achieved by consuming with meals that contain fat.
Children and pregnant or lactating women should consult their healthcare practitioner prior to use. Do not use if tamper seal is damaged.
Does Not Contain:
Wheat, gluten, corn, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.
- Mabuchi H, Nohara A, Kobayashi J, et al. Hokuriku Lipid Research Group. Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: a randomized double-blind study. Atherosclerosis. 2007 Dec;195(2):e182-89. [PMID: 17681347]
- Dai YL, Luk TH, Yiu KH, et al. Reversal of mitochondrial dysfunction by coenzyme Q10 supplement improves endothelial function in patients with ischaemic left ventricular systolic dysfunction: a randomized controlled trial. Atherosclerosis. 2011 Jun;216(2):395-401. [PMID: 21388622]
- Zeb I, Ahmadi N, Nasir K, et al. Aged garlic extract and coenzyme Q10 have favorable effect on inflammatory markers and coronary atherosclerosis progression: A randomized clinical trial. J Cardiovasc Dis Res. 2012 Jul;3(3):185-90. [PMID: 22923934]
- Alehagen U, Johansson P, Björnstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2012 May 22. Epub ahead of print. [PMID: 22626835]
- Lee BJ, Huang YC, Chen SJ, et al. Coenzyme Q10 supplementation reduces oxidative stress and increases antioxidant enzyme activity in patients with coronary artery disease. Nutrition. 2012 Mar;28(3):250-55. Epub 2011 Oct 12. [PMID: 21996047]
- Mischley LK, Allen J, Bradley R. Coenzyme Q10 deficiency in patients with Parkinson’s disease. J Neurol Sci. 2012 Jul 15;318(1-2):72-75. Epub 2012 Apr 27. [PMID: 22542608]
- Binukumar BK, Gupta N, Bal A, et al. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic coenzyme Q10 pretreatment. Toxicol Appl Pharmacol. 2011 Oct 1;256(1):73-82. [PMID: 21843543]
- Bliznakov EG. Immunological senescence in mice and its reversal by coenzyme Q10. Mech Ageing Dev. 1978 Mar;7(3):189-97. [PMID: 304510]
- Puertollano MA, Puertollano E, de Cienfuegos GÁ, et al. Dietary antioxidants: immunity and host defense. Curr Top Med Chem. 2011;11(14):1752-66. [PMID: 21506934]
- Liu J, Wang L, Zhan SY, et al. Coenzyme Q10 for Parkinson’s disease. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD008150. Review. Update in Cochrane Database Syst Rev. 2012;5:CD008150. [PMID: 22161420]
- Berthold HK, Naini A, Di Mauro S, et al. Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomized trial. Drug Saf. 2006;29(8):703-12. [PMID: 16872244]
- Rundek T, Naini A, Sacco R, et al. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. Arch Neurol. 2004 Jun;61(6):889-92. [PMID: 15210526]
- Munkholm H, Hansen HHT, Rasmussen K. Coenzyme Q10 treatment in serious heart failure. Biofactors. 1999;9(2-4): 285-89. [PMID: 10416042]
- Figuero E, Soory M, Cerero R, et al. Oxidant/antioxidant interactions of nicotine, Coenzyme Q10, Pycnogenol and phytoestrogens in oral periosteal fibroblasts and MG63 osteoblasts. Steroids. 2006 Dec;71(13-14):1062-72. [PMID: 17045317]
- Study available upon request.